ABSTRACT
In the period of regular epidemic prevention and control of Coronavirus disease 2019 (COVID-19) in our country, work resumption has been fully advanced. But there are still new sporadic local cases and imported cases across the country. In this situation, whether kindergartens reopening will increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread still remains uncertain. We reviewed two pediatric patients with moderate COVID-19, collected the epidemiologic information and monitored the cycle threshold value of rectal specimen and the viral loads, and discussed the transmission of SARS-CoV-2 in pediatric patients and the virulence of feces in children with moderate COVID-19, in order to analyze the risk of kindergartens reopening.
Subject(s)
Betacoronavirus/isolation & purification , Coronavirus Infections/prevention & control , Feces/virology , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Betacoronavirus/genetics , Betacoronavirus/pathogenicity , COVID-19 , Child, Preschool , China/epidemiology , Coronavirus Infections/epidemiology , Coronavirus Infections/transmission , Female , Humans , Pandemics/statistics & numerical data , Parents , Pneumonia, Viral/epidemiology , Pneumonia, Viral/transmission , SARS-CoV-2 , Schools , Viral Load , Virus SheddingABSTRACT
The SARS-CoV-2 infection status of hospitalized children was surveyed in the department of pediatric hematology and oncology in three different hospitals of epidemic areas in Hubei, China. A cross-sectional study was performed to investigate the clinical characteristics, lung CT scan, SARS-CoV-2 nucleic acid test and serum antibodies of hospitalized children with hemato-oncological diseases from January 23 to April 24, 2020. 299 children were enrolled in this study, including 176 males (58.9%) and 123 females (41.1%), aged from 2 months to 16 years. 255 cases (85.3%) received chemotherapy or other immunosuppressive therapies, and there were 44 cases (14.7%) of other benign diseases. Nucleic acid test was performed on 258 children (86.3%) and one case was positive. 163 cases (54.5%) were tested for serum antibodies, and all of them were negative. Lung CT scan was performed on 247 children (82.6%), and 107 of them showed infectious changes. Only one case (0.33%) of COVID-19 was diagnosed in the group. The prevalence rate of COVID-19 in enrolled children with hemato-oncological diseases in Hubei was 0.33%. Immunosuppressed patients are not prone to produce related antibodies. Comprehensive protective measures and ward management can reduce the risk of SARS-CoV-2 infection in the group patients.
Subject(s)
Betacoronavirus , Coronavirus Infections/epidemiology , Hematologic Diseases/epidemiology , Neoplasms/epidemiology , Pandemics , Pneumonia, Viral/epidemiology , Adolescent , COVID-19 , COVID-19 Testing , Child , Child, Hospitalized , Child, Preschool , China/epidemiology , Clinical Laboratory Techniques/methods , Comorbidity , Coronavirus Infections/diagnosis , Coronavirus Infections/prevention & control , Cross-Sectional Studies , Female , Humans , Infant , Infection Control , Male , Mass Screening , Pandemics/prevention & control , Pneumonia, Viral/diagnosis , Pneumonia, Viral/prevention & control , Prevalence , Risk Factors , SARS-CoV-2 , Surveys and QuestionnairesABSTRACT
Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of "Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital". This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns.